Cancer research today : invasion and metastasis.

London : University of London Audio-Visual Centre, 1974.

1 encoded moving image (46.05 min.) : sound, black and white.

00:46:05

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr Gerald Easty, Professor Jack Ambrose and Dr Richard Carter. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Easty describes the difference between malignant and benign tumours in terms of their cellular structure. He shows a series of illustrations documenting the growth of a tumour, then a photograph of invading tumour cells. A further illustration is used to show how enzymes facilitate invasion. Time start: 00:00:00:00 Time end: 00:06:13:00 Length: 00:06:13:00

Segment 2 Easty shows a graph which details the area of a tumour where enzymes are most active. He explains how tumours stimulate the proliferation of connective tissue cells in their vicinity. Time start: 00:06:13:00 Time end: 00:11:46:00 Length: 00:05:23:00

Segment 3 Ambrose takes over from Easty and discusses how a normal cell changes into a tumour cell. A short film is shown in which Easty demonstrates the method of preparing a chorioallantoic membrane for an organ culture. Film clip ends. Time start: 00:11:46:00 Time end: 00:18:39:00 Length: 00:06:53:00

Segment 4 Ambrose shows an enlarged model of a chick chorioallantoic membrane. A time-lapse film is played which shows different types of cell on a chick chorioallantoic membrane culture. Film clip ends. Time start: 00:18:39:00 Time end: 00:22:43:00 Length: 00:04:04:00

Segment 5 Ambrose shows a diagram which details changes at a molecular level in cancer cells. He then demonstrates filament patterns in normal and malignant cells, using a cocktail stick. Time start: 00:22:43:00 Time end: 00:26:36:00 Length: 00:03:53:00

Segment 6 Carter takes over from Ambrose and discusses metastatic processes. He shows histograms of two different breast cancers and a series of illustrations detailing the invasion of primary tumours. Time start: 00:26:36:00 Time end: 00:32:12:00 Length: 00:05:36:00

Segment 7 Carter shows illustrations of metastatic tumour cells via the lymphatic system, then via the blood system. He shows diagrams and histograms which detail the behaviour of circulating tumour cells, then arrested cells in the blood. Time start: 00:32:12:00 Time end: 00:38:59:00 Length: 00:06:47:00

Segment 8 Carter shows illustrations demonstrating the function of soil factors, then diagrams showing the experimental grafting of tomour cells onto hamsters. A table is used to list immune cells and antibodies involved in metastasis. Carter rounds up the lecture. Time start: 00:38:59:00 Time end: 00:46:05:01 Length: 00:07:06:01