Three cases of tumour arising from skin-glands in the dog : showing the connection between disorder of the glandular structure and function and cancerous invasion of the connective tissue / by Charles Creighton.

  • Creighton, Charles, 1847-1927.
Date:
1882
Catalogue details

Licence: Public Domain Mark

Credit: Three cases of tumour arising from skin-glands in the dog : showing the connection between disorder of the glandular structure and function and cancerous invasion of the connective tissue / by Charles Creighton. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    TUMOURS ARISING PROM often to be seen in large numbers beside them, they must lose their granular substance and become reduced to a nuclear state before they begin to divide. The third factor in the formation of tumour No. 2 is the cancerous infection of the fixed connective-tissue cells of the corium; and inasmuch as that important subject is better illustrated by the appearances in tumour No. 3, I shall include what remains to be said of tumour No. 2 in the next section. III. Cancerous infection of the corium and subcutaneous connective tissue, following on disorder of the structure and function of shin-glands. Tumour No. 3 was a circular fungus-like growth in the skin of the back, with a thin upper stratum in a state of slough. It was of scirrhous hardness, and in minute structure it consisted of a dense stroma everywhere split up into numerous narrow bands, the meshes or alveolar spaces enclosing exquisitely-formed epithelial cells of-a cubical or polyhedric shape with a nucleus and finely granular or homogeneous protoplasm. The tumour was evidently a cancer, but it was at the same time not an epithelioma ; and it was not clear at first sight how such a tumour could be connected with any cutaneous structure. However, a more careful search within the area of the tumour brought to light two or three clusters of skin- glands ; and, by way of furnishing evidence on that important point, I have drawn in fig. 8 a group of three or four such glandular crypts exactly as they lay in the midst of a tract of the stroma of the tumour. The basket- work of plain muscular fibres can nowhere be seen more clearly than in some of these tubules, and the size and form of the epithelial cells are equally distinctive. The skin-glands have been the point of departure of tumour No. 3, as of tumours Nos. 1 and 2, but in the third tumour it is more difficult to trace its structure back to the