On the chemistry and therapeutics of uric acid gravel and gout : being the Croonian lectures for 1892 ... with additions / by Sir William Roberts.

Date:
1892
Catalogue details

Licence: Public Domain Mark

Credit: On the chemistry and therapeutics of uric acid gravel and gout : being the Croonian lectures for 1892 ... with additions / by Sir William Roberts. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    Table N.—Com;plete Quantitative Analysis of the Urine of tJie Boa, Ten grams yielded :— Uric acid 8-280 grams Potassimn 0-333 „ Sodium 0-100 „ Ammonium 0-192 „ Moisture, organic matter, and iron—with traces of lime—and loss . . . 1-089 „ 10-000 „ Uric acid combined as quadri-urate with the bases present 8-071 „ Free uric acid 0-209 „ The results of this analysis came out closely in accordance with the requirements of the quadri-urate hypothesis. The quantity of uric acid over and above that requu'ed to form quadri-urates with the bases present, and which might be regarded as existing in the free state, did not exceed 2-5 per cent, of the total uric acid found. C. ANALYSES OF ABTIFICIALLY-PBEPABED QUADBI-UBATES As already stated, Bence Jones succeeded in prepar- ing compounds of uric acid with potassium and sodium which were decomposable by water, by adding acetic acid to cold solutions of uric acid in potash or soda ley until a precipitate was produced. This method was, however, found to give very uncertain results. If the acetic acid was added a little too freely, the precipitate was contaminated with free uric acid; and, on the con- trary, if too little acetic acid was added, the precipitate was contaminated with bi-urate; it was almost impos- sible to hit the mark with precision. The following