Carcinoma mammae in the mouse / by E.F. Bashford and J.A. Murray.

  • Bashford, Ernest Francis, 1873-
Date:
[1907]
Catalogue details

Licence: In copyright

Credit: Carcinoma mammae in the mouse / by E.F. Bashford and J.A. Murray. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    appear as roughly spherical swellings usually placed asymmetrically with reference to the nipple as in the human subject. The small size o£ the mouse, and the looseness of its integuments often permit this shape to be retained till the increase in size is incompatible with existence, there being a limit to the amount of tissue which the animal can support. The looseness and elasticity of the skin may permit growth to proceed without invasion of the chest wall in tumours in the axillary Fig. 5.—Transverse section of a mouse with spontaneous carcinoma mammse (19). a. Hypertrophied normal mamma (lactation), b. Cystic mamma anterior to growth, c. Mass of growth replacing left lung, lower lobe. Fig. 6.—Transverse section of same mouse through growth at level of diaphragm. a. Normal mamma, b. Growth, c. Posterior end of growth in left lung. d. Metastasis in right lung, upper lobe. region, although the lungs may be almost completely replaced by metastatic growths. Lymphatic glands in the neighbourhood may also present secondary deposits, as in figs. 7, 9, and 11. These mammary growths frequently appear, on removal of the skin, to be encapsuled completely by a fibrous layer of varying thickness. This “ capsule,” however, is usually invaded by strands and columns of tumour cells, as in the accompanying figure (fig. 8). The complete surgical removal of the tumours can be effected only by removing the capsule and