Contribution to the study of the vertebrate liver / by Sheridan Delépine ; communicated by T. Lauder Brunton. Received November 20, 1890.

  • Delépine, Sheridan, 1855-1921.
Date:
[1891]
Catalogue details

Licence: Public Domain Mark

Credit: Contribution to the study of the vertebrate liver / by Sheridan Delépine ; communicated by T. Lauder Brunton. Received November 20, 1890. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    [From the Proceedings of the Royal Society, Vol. 49.] Contribution to the Study of the Vertebrate Liver. By Sheridan Delepine, M.B. Edin. Communicated by T. Lauder Brunton, M.D., D.Sc., F.R.S. Received N<>- vember 20, 1890. (Abstract.) Preliminary Remarks.—The following observations were made at the end of last year in the course of an investigation touching the action of drugs on cellular structure carried out by Dr. Lauder Brunton and myself, for the Royal Society. Arrangement of the Hepatic Columns in a Classical Liver Lobule.^ - The following arrangement is visible in a plane perpendicular to the direction of the terminal vessels occupying the centre and the peri- phery of such a lobule. The columns of cells extend radially round the hepatic veins only in the direction of the portal veins, that is, in three, four, or five directions at most. In the intermediate region the columns present a typical feathery arrangement. The line from which the columns diverge will be called hereafter hepatic line of divergence. A similar arrangement is found around the terminal portal veins, giving rise to what I call portal lines of divergence. Towards the portal lines of divergence the columns of cells become smaller in diameter, and join each other, becoming continuous with narrow tubes lined with flat epithelium and having the character of intermediate tubes. These narrow channels open into more distinct terminal bile ducts. Arrangement of the Bile Canaliculi.—The liver columns branch from the portal lines of divergence towards the hepatic lines. This branching is, however, generally obscured by lateral anastomoses, but it becomes more evident when the bile canaliculi are distinct. Two sets of bile canaliculi may be recognised : 1. The main canaliculi, occupying the axis of the columns of cells and becoming comparatively wide in the portal zone ; it is the branch- ing of these which renders that of the columns so evident in some specimens. 2 The lateral canaliculi, which pass between the cells Forming the walls of the main canaliculi.