Contribution to the study of the vertebrate liver / by Sheridan Delépine ; communicated by T. Lauder Brunton. Received November 20, 1890.

  • Delépine, Sheridan, 1855-1921.
Date:
[1891]
Catalogue details

Licence: Public Domain Mark

Credit: Contribution to the study of the vertebrate liver / by Sheridan Delépine ; communicated by T. Lauder Brunton. Received November 20, 1890. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    Mr. S. Delepine. Contribution to the [Dec. 18, In addition to these two sets of passages an intracellular branched system of lacunce may be described as forming the rootlets of the canaliculi. These spaces open directly into the canaliculi, and have been previonsly partly described by Pfliiger and Kupffer. Description of a True, Secretory, or Primary Lobule.—From'what precedes it follows that the liver tnbes, instead of being grouped round the terminal hepatic veins, are distinctly arranged in small pyramidal masses, which correspond to the lobules of other glands. These lobules are composed of the tubules diverging from the intermediate tubes found in the portal line of divergence, each set of intermediate tubes opening into a terminal bile duct. An arrangement somewhat analogous had already (in 1882) been supposed to exist by Sabourin, but he had been unable to discover in healthy livers what he believed to exist and had been obliged to fall back upon diagrammatic repre- sentations which are not altogether correct. Development of the Liver.—Dberth and other observers since have recognised that the embryonic liver is composed of hypoblastic tubes branching in a mass of mesoblast. This being common to the liver and all other glands does not explain the differences between these organs. Between the third and sixth weeks of embryonic life (in man) nearly the whole of the mesoblastic tissue separating the hypo- blastic columns becomes transformed into embryonic veins full of blood. In other glands only a small part of that tissue becomes transformed into veins, the greater part remaining in the shape of interlobular and interlobar tissue. In the liver, therefore, the hepatic veins take the place of the greater part of the stroma of other glands. It is only around the oldest hypoblastic tubes which become ulti- mately ducts, and at the periphery of the organ, that a little meso- blastic tissue becomes transformed into fibrous connective tissue (Glisson's capsule). Structure of the Hepatic Cells—-The mitoma gives unmistakable evidence of a further differentiation of parts of the trabecular com- posing it. These trabecule are contractile. The paramitoma is enclosed in the meshes formed by the mitoma, and is the chief seat of the anabolic and katabolic- changes taking place in protoplasma. The products thus formed probably under the influence of the mitoma accumulate in the midst of the paramitoma ; when soluble, they permeate it; when insoluble, they are precipitated in the shape of drops or vacuoles, globules, granules, crystals. For these products only the name of Faraplasma should be reserved. In the paraplasma two kinds of elements may be recognised, namely: (1) those resulting from the katabolic process of the cell or other tissues (kataplasma), e.g., bile pigment; (2) those result- ing from the anabolic processes (anaplasma), e.g., glycogen In the